Hey everyone! 
The Nextflow Podcast is back! 
After an extended hiatus in the second half of 2025 (house renovations - don’t ask), Episode 53 kicks off 2026 with a comprehensive year-in-review!
I’m joined by @robsyme, @mribeirodantas, and @robnewman to recap everything that happened in the Nextflow ecosystem over the past year. Spoiler: it was a lot.
Nextflow Language Evolution:
- Strict syntax with the new
NXF_SYNTAX_PARSER=v2parser nextflow lintandnextflow formatcommands- VSCode extension with a proper language server (finally!)
- Lineage tracking for full data provenance
- New plugin registry at registry.nextflow.io
- AWS SDK v2 rewrite for dramatically better S3 performance
- Workflow inputs/outputs and the foundations for static types
Seqera Platform Updates:
- Redesigned Pipeline Run Details page
- Single-VM compute environments (4-6x faster startup!)
- Seqera Compute with $100 free credits
- Fusion Snapshots for spot instance resilience
- Studios improvements including git integration
- Data Explorer S3-compatible API support
- MCP server for Claude/Cursor/Copilot integration
- Node-RED for pipeline chaining and automation
Community Highlights:
- nf-core tools 3.3, 3.4, 3.5 releases
- Topics adoption and syntax roadmap through 2027
- Summits in Boston and Barcelona
- Ambassador program now in 40 countries with 600+ activities
- Training Weeks with 1,000+ registrations
- Series B funding and SOC 2 certification
Key resources mentioned:
- Nextflow Plugin Registry
- nf-core Syntax Adoption Roadmap
- Seqera MCP Server
- Node-RED Integration
- Fusion Snapshots
- Nextflow Summit Barcelona 2025 Recordings
Show notes, transcript, links and more: https://seqera.io/podcasts/episode-53-recap-2025/
The episode is available now on YouTube, Spotify, and all other podcast platforms! 
The podcast page has a detailed summary plus full transcript for easy reading. The subtitles are also manually curated so should be pretty good quality.
What were your favourite developments from 2025? Anything we missed? Let us know below!
